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Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

10.1016/j.intimp.2020.107193 8 AshiruO.HoweJ

It is a leading contributor to disability and premature mortality in the world 3,4

This suggests a significant likelihood that one drug will out-compete or saturate the renal excretion pathways prior to the elimination of the other co-administered drugs, leading to inhibited or delayed clearance